Professor Charlotte Coles
Prof Charlotte Coles is an National Institute of Health Research (NIHR) Research Professor and Reader in Breast Radiation Oncology at the Cancer Research UK Cambridge Centre, UK. Her research aims are to provide breast cancer patients with the best chance of cure with least side effects by personalising radiation techniques based on risk of recurrence. She is Chief Investigator of 4 clinical trials with linked translational research:
1. IMPORT LOW: phase III randomised trial (RCT) investigating intensity modulated radiotherapy (IMRT) and partial breast radiotherapy in patients at low risk of recurrence – in follow up: 2018 patients recruited; 71 UK centres
2. IMPORT HIGH: phase III RCT investigating dose-escalated IMRT for patients at higher risk of recurrence – in follow up: 2617 patients recruited; 77 UK centres
3. PRIMETIME: prospective cohort investigating post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers – open: 45 UK centres to date
4. NEO-RT: feasibility study investigating pre-operative breast IMRT in patients receiving neo-adjuvant hormonal treatment – open: 2 UK centres
Prof Coles is also Chair of the UK National Cancer Research Institute Breast Clinical Studies Early Disease Subgroup, Editor-in-Chief of Clinical Oncology journal and lead for the Cambridge Cancer Research UK Cambridge RadNet Unit.