Dr Gillian Farnie

University Research Lecturer, University of Oxford

Dr Gillian Farnie

University Research Lecturer, University of Oxford
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Biography

Gillian Farnie leads a research team focused on breast cancer resistance at the University of Oxford. Her research investigates how cancer stem cells (CSC) contribute to treatment resistance and tumour recurrence/metastasis to discover new targets to eliminate these treatment resistant populations. To support these studies the Farnie Lab utilise PDX which are key for measuring CSC tumour initiating frequency, the gold standard CSC assay but also develop in vitro models to recapitulate the patient environment as closely as possible to measure CSCs in their complex tumour microenvironment.

These in vitro models include; 1) peptide hydrogels that can be tailored to independently assess human extracellular matrix and tissue stiffness throughout breast cancer progression, 2) patient tissue ex-plant models which harness the inherent complexity of the tissue, maintaining epithelial proliferation, hormone signalling and cellular complexities of stromal/immune cells.