Rob Clarke is a Professor of Breast Biology and Director of the Manchester Breast Centre at The University of Manchester. He is based in Manchester Cancer Research Centre and his research interests are human breast development and cancer.
Rob was first author of the first ever ‘window of opportunity’ presurgical trial in cancer to use Ki67 (proliferation) as an endpoint. He established the paracrine factor paradigm for local signalling induced by systemic hormones in breast tissues, regulating proliferation and stem cells, and discovered the importance of Notch receptor signalling in human breast development and cancer. The papers describing these discoveries have been cited more than 5,000 times.
More recently, he has been developed numerous patient-derived models of human breast cancer, both in vitro and in vivo, including patient-derived xenograft tumours of all molecular sub-types of breast cancer.